Investigation of Thymidylate synthase gene polymorphism in colon cancer patients
A Schöller, A Kalmár, VÁ Patai, Z Nagy, B Barták, O Galamb, S Spisák, L Sréter, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Thymidylate synthase enzyme is essential for DNA repair and biosynthesis and it is involved in cell proliferation as well. A 28bp variable tandem repeat (VNTR) a G/C single nucleotid polimorphism at the 5'UTR and a deletion of 6bp at the 3'UTR were described. Thymidylate synthase is the therapeutic target of 5-fluorouracil based chemotherapy and its alterations could change the therapeutic response. Aims: Our aims were to compaire the thymidylate synthase polimorphism between healthy tissue and colon cancer and examinate the efficacy of 5-FU according to genetic variants. Materials and methods: The r…
