NALP3 inflammasome activation is MYD88-, but not TLR4-dependent and involves both parenchymal and bone marrow derived cells in non-alcoholic steatohepatitis (NASH)
T Csak, A Villai, M Ganz, D Lippai, J Petrasek, B Nath, K Kodys, A Dolganiuc, E Kurt-Jones, G Szabo · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and Aims: Endogenous danger signals from damaged hepatocytes in NASH might up-regulate and activate the inflammasome, that is a multiprotein complex that leads to IL-1ß secretion. We reported NALP3 inflammasome up-regulation activation in NASH. Here, we aimed to investigate the role of toll-like receptor 4 (TLR4) and the common TLR adaptor, MyD88 in the activation of NALP3 inflammasome. Furthermore, we aimed to investigate which cell types are involved in the inflammasome activation in the liver in NASH. Methods: Wild type (WT), TLR4- and MyD88-deficient (KO) mice, and WT mice transplanted with MyD88…
