Contribution of Keratin-18 on steatohepatitis and liver cancer
K Bettermann, AK Mehta, E Lederer, C Diwoky, A Thüringer, H Müller, VS Mahajan, C Stumptner, T Kolbe, TM Magin, H Denk, C Lackner, K Zatloukal, J Haybaeck · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Steatohepatitis (SH) is morphologically characterized by steatosis, hepatocyte ballooning and cytoplasmic protein aggregates termed Mallory-Denk bodies (MDBs). SH arises in about 20% of alcoholics and is tightly associated with obese type II diabetics. MDBs are generally composed of misfolded keratin (K) 8, 18 and in part p62 and ubiquitin. It is well established that Keratin aggregates are critical for MDB formation, thus keratins are associated with SH which is one of the main preconditions for the development of liver cirrhosis and hepatocellular carcinoma (HCC). Aims: In this study we aimed to cl…
