11-Keto-β-boswellic acid inhibits infiltration of lymphocytes into pancreatic islets in NOD-mice

Introduction: Previously we have shown that 11-Keto-β-boswellic acid (KBA) and O-acetyl-11-Keto-β-boswellic acid (AKBA) prevent hyperglycemia, infiltration of lymphocytes into pancreatic islets and the increase of proinflammatory cytokines in the model of multiple low dose-streptozotocin (MLD-STZ) diabetic mice (Ammon and Shehata, 2011). Aim of study: It was aimed to study whether or not such an effect could also be observed in NOD-mice which develop a genetically type 1 diabetes similar to human type 1 diabetes. Methods: Female NOD mice 4 weeks of age (Charles River) were i.p. injected for 3 weeks with 7.5mg/kg…