CareLit Fachartikel

Immunization profiles and progression of islet autoimmunity in children at type 1 diabetes risk

R Chmiel, S Krause, A Knopff, C Matzke, D Höfelmann, J Schenkel, AG Ziegler, P Achenbach · Diabetologie und Stoffwechsel · 2012 · Heft 05

Dokument
1017786
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Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
R Chmiel, S Krause, A Knopff, C Matzke, D Höfelmann, J Schenkel, AG Ziegler, P Achenbach
Ausgabe
Heft 05 / 2012
Seiten
–
Erschienen: 2012-05-08 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0032-1314464

Zusammenfassung

Aim: To determine islet autoantibody profiles at time of seroconversion and track changes in antibody profiles on follow-up (1–2 years after seroconversion) with respect to age at first antibody appearance, genetic predisposition and rate of progression to type 1 diabetes (T1D). Methods: Islet autoantibodies (IAA, GADA, IA-2A, IA-2βA, ZnT8A) were measured in follow-up serum samples of 142 confirmed autoantibody-positive children from the BABYDIAB study (median follow-up from birth 11.7 years). Antibody binding to epitope regions on GAD65 (NH2, MID, COOH) and IA-2 (JM, PTP), polymorphic variants of ZnT8 (R325, W3…

Schlagworte

Diabetologie und Stoffwechsel