Morphological lung differences in an asthma mice model can be entangled applying the concept of fractal geometry to high-resolution flat-panel Computed Tomography images – a preli…

Introduction: We want to describe quantitatively the variation of the morphological appearance of radiological lung images in two murine models of experimental asthma. Materials and Methods: Four Balb/c mice were used in an acute and four C57Bl/6 mice in a chronic asthma model using Ovalbumin (OVA) as an allergen. OVA-sensitized and Sham-sensitized Balb/c and C57Bl/6 mice were exposed to inhaled allergen on three consecutive days (acute) or on two consecutive days up to four weeks (chronic). A flat-panel based CT scan (eXplore Locus Ultra) was performed before and after stimulation of an asthma attack induced by…