Role of Notch Signaling in Pulmonary Hypertension

Pulmonary Hypertension (PH) is a disease condition characterized by excessive pulmonary vascular remodeling leading to increased vascular resistance and ultimately death due to right heart failure. Notch Signaling is an evolutionarily conserved mechanism, functioning during various developmental and physiological processes. Notch signaling molecules are not only instrumental in physiological processes, but also key mediators in pathological conditions, including chronic lung diseases. Hence, we hypothesized that Notch may be involved in pathogenesis of PH. Expression of Notch family genes was investigated in lun…