Dll4 and Jagged-1 improve liver fibrosis dependent of etiology
Y Liu, Z Shen, MY Xu, C Meyer, S Munker, Q Li, I Ilkavets, R Müllenbach, P ten Dijke, J Li, S Dooley, LG Lu, Y Li, HL Weng · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: Humans have five Notch ligands (Jagged1, Jagged2, Delta like ligand (Dll)1, Dll3 and Dll4) and four receptors (Notch1, 2, 3 and 4). Mutation of Jagged-1 and Notch2 leads to Alagille syndrome, a disease characterized by defective development of intralobular bile ducts. Notch signaling drives hepatic progenitor cells differentiation into cholangiocytes during acute and chronic hepatic regeneration. It remains obscure whether Notch family proteins play a role in liver fibrosis. Here we investigated effects of Notch ligands in HBV-infected patients and experimental models. Methods: Genechip anal…
