Stammzellveränderung bei MDS

Myelodysplastic syndromes (MDS) are clinically characterized by two important features: ineffective hematopoiesis leading to bone marrow failure and a propensity to transform to acute myeloid leukemia (AML). Although the pathophysiology is not entirely understood there is large body of evidence that the disease phenotype originates from the compartment of hematopoietic stem cells (HSC) in the bone marrow. In fact, the HSC origin of the disease also explains why allogeneic hematopoietic stem cell transplantation (HSCT) is, still, the only potentially curative option for these patients. Although several abnormalit…