CareLit Fachartikel

Role of ATP and purinergic-receptors-signalling in the pathogenesis in the ALI/ARDS

S Cicko, T Mueller, K Ayata, A Zech, K Baudiß, M Braun, A Meyer, M Grimm, S Sorichter, M Idzko · Pneumologie · 2012 · Heft 11

Dokument
1018282
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Cicko, T Mueller, K Ayata, A Zech, K Baudiß, M Braun, A Meyer, M Grimm, S Sorichter, M Idzko
Ausgabe
Heft 11 / 2012
Seiten
–
Erschienen: 2012-11-13 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1329804

Zusammenfassung

Background: Extracellular ATP serves as a danger signal to alert the immune system of tissue damage by acting on P2X or P2Y receptors. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterized by rapid alveolar injury inflammation, cytokine induction, neutrophils accumulation and vascular leakage leading to lung oedema. While recent data point out to an important role of ATP/P2R-axis in chronic inflammatory lung diseases such as asthma and COPD, its role in ALI/ARDS is unknown. Aims: To investigate the role of ATP and purinergic-receptors-signalling in the pathogenesis in the ALI/ARDS M…

Schlagworte

Pneumologie