Increased expression of c-jun in nonalcoholic fatty liver disease
C Dorn, J Engelmann, M Saugspier, A Hartmann, M Müller, R Spang, A Bosserhoff, C Hellerbrand · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
The lack of animal models which closely mimic the human situation is one main reason why the molecular mechanisms causing progression from nonalcoholic fatty liver to (NASH) still are elusive. In addition to the quantity of consumed calories, certain dietary components, namely saturated fatty acids, fructose, and cholesterol are increasingly recognized as dietary factors affecting NAFLD progression. The aim of this study was to developed and characterize a NASH inducing diet (ND) containing these nutrients in a composition which mimics Western food. Methods and Results: Feeding ND to male C57Bl6/N mice for 12 we…
