Rat model of long term effects after fractionated (2Gy/day) 60Gy irradiation of rat liver

Background:The application of radiotherapy in liver tumours is limited by supposed sensitivity of liver tissue (RILD). However liver focused application of a high single dose irradiation (HDI) on healthy liver has mild acute consequences. Consequences of fractionated irradiation (FI) of the rat liver have not yet been studied. Materials and Methods: Rats were exposed to a liver-focused (by CT-scan) fractionated irradiation (total dose of 60Gy, 2Gy/day and 5 days/week) or high single dose irradiation (25Gy) on liver tissue. Irradiated animals were sacrificed at 1, 3, 6, 12, 24, and 48 and 96h (25Gy) at 3 months a…