Differential localization of iron transport proteins in rat liver and spleen during acute phase response

Liver is the major organ for iron metabolism. During acute phase response, the hepatic iron concentration increases together with an increase in hepatic expression of iron import proteins. However, less is known about the cellular localization of iron transport proteins. Current study aimed to compare cellular localization of iron-transport-protein ferroportin-1-(Fpn-1) and of other iron-import-proteins in rat liver after experimental tissue damage induced by injecting turpentine-oil-(TO) in both hind-limbs. Immunohistochemistry of DMT-1 and TfR2 (iron import proteins) were mainly detected in the nucleus of cont…