Effect of immunosuppressive drugs on regulatory T cells after liver transplantation

Background and aims: HCV-related end-stage cirrhosis is the most common indication for liver transplantation in Western countries. Unfortunately, reinfection of the liver allograft is universal. Regulatory T cells (Tregs) are thought to be involved in determining the balance between antiviral and allogeneic immune responses. The aim of this study was to assess the effect of immune suppressive and antiviral drugs on the Treg population. Methods: Peripheral blood mononuclear cells (PBMCs) were incubated with immune suppressive drugs (Cyclosporin A (CsA), Tacrolimus, MMF, Everolimus, Prednisolon) and anti HCV drugs…