Upcyte® Hepatocytes show stable phenotype characteristics of human hepatocytes

Aims: The low availability of human liver tissue causes a limited supply of much needed primary human hepatocytes. To address this problem, Medicyte has developed a new technology which induces the ability of human hepatocytes to proliferate by transducing the cells with genes enabling cell proliferation. The aim of this work was to elucidate gene expression and metabolic characteristics of these specially modified liver cells called upcyte® Hepatocytes at different stages of expansion. Material and Methods: Upcyte® Hepatocytes from different donors were cultured for three expansion stages, over ˜20 Population D…