A p19Arf and Aurka mediated G2/M arrest prevents oncogenic transformation of p53 deficient hepatocytes
D Dauch, T Wuestefeld, TW Kang, R Rudalska, A Hohmeyer, L Hoenicke, JC Nault, T Yevsa, P Schirmacher, MP Manns, T Longerich, J Zucman-Rossi, L Zender · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
The tumor suppressor protein p19Arf (p14 in human) is known as an important linker between oncogenic induction and activation of p53. However, also p53 independent functions of p19Arf are under discussion. To identify tumor suppressive networks of p19Arf and p53 in hepatocellular carcinoma (HCC), we established a new approach to deliver oncogenes and marker genes in combination with shRNAmir induced gene knockdown into murine hepatocytes via transposable elements. Parallel analyses of NrasG12V driven hepatocarcinogenesis revealed striking differences of tumor onset in different genetic backgrounds. Whereas NrasG…
