αLβ2-integrin is indispensable for CD4+ and CD8+ T cell recruitment in hepatocellular cancer

Background/Aim: Recruitment of activated leukocytes from peripheral blood into the tumor tissue is a crucial step of the immune response. In normal tissue, this process is usually controlled by the interactions between adhesion molecules such as endothelial ICAM-1 and leukocyte β2-integrins. The mechanisms of leukocyte recruitment in tumor tissue are poorly understood. The aim of the present study was to investigate the role of ICAM-1 and LFA-1 (αLβ2-integrin) in leukocyte recruitment in hepatocellular cancer in vivo. Methods and results: We used transgenic (AlbTag) and transplantable (Hep55.1C) HCC tumors from…