IL-28B Genotype is not associated with early HCV-RNA negativity in patients with symptomatic acute HCV infection
K Deterding, N Grüner, P Buggisch, J Wiegand, PG Galle, U Spengler, H Hinrichsen, T Berg, A Potthoff, NP Malek, A Großhennig, A Koch, H Diepolder, S Lüth, S Feyerabend, MC Jung, M Rogalska-Taranta, V Schlaphoff, M Cornberg, MP Manns, H Wedemeyer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Patients with acute hepatitis C are able to cure the infection spontaneously in 10–50% of cases. Factors being associated with spontaneously clearance are female sex, viral load, early HCV RNA declines kinetics and symptoms of hepatitis at presentation. The IL-28B genotype has also been associated with clearance of HCV infection but controversial data have been published in patients with symptomatic versus asymptomatic acute hepatitis C. Methods: We analysed data from the German Hep-Net-Acute-HCV-III study which was designed in 2004 as a prospective, randomized trial in patients with symptomatic acute hepatitis…
