The IL-6/GP130 signaling pathway in myeloid cells modulates the inflammatory response during sepsis

Background and Aim: Ascites and its bacterial infection (SBP) is a frequent and dangerous complication in patients suffering from liver cirrhosis. After bacterial peritonitis, the mobilization of the regulatory myeloid cells is a major requirement to prevent sepsis. Current research on inflammatory pathways has shown that GP130 in hepatocytes is essential in the modulation of inflammation. Therefore, we investigated the contribution of the GP130 pathway for the skewing of macrophage towards the regulatory M2 phenotype in a model of peritonitis. Methods: Depletion of GP130 in hematopoietic cell-deficient mice was…