Ceramide-1-Phosphate attenuates cigarette smoke induced lung inflammation

Sphingolipids are playing an essential role in normal cell und tissue homeostasis as well as in the development and progress of various diseases and disorders. The central molecule in the sphingolipid metabolism is ceramide, which has been shown to regulate vital cellular functions such as apoptosis, cell growth, differentiation, and important disease pathomechanism in inflammation. An important metabolite of ceramide is Ceramide-1-Phosphate (C1P), which is generated through direct phosphorylation of ceramide by ceramide kinase. While the role of Shingosine-1-Phosphate in the pathogenesis of airway inflammation…