Minor role of fatty acid for mitochondial metabolism during insulin secretion

Aims: An appropriate insulin secretion by pancreatic beta-cells is necessary to maintain glucose homeostasis. In these cells a rise in plasma glucose results in an increased metabolism and an elevated cytoplasmic ATP/ADP ratio that finally triggers insulin granule exocytosis. In addition to this triggering pathway one or more amplifying pathways – activated by amino acids or fatty acid – enhance secretion by promoting insulin granule recruitment to, and priming at, the plasma membrane. The aim of this study was to clarify to which extend fatty acids increase insulin secretion via mitochondrial respiratory activi…