The metabolic relevance of the UDP-glucose receptor P2Y14

Introduction: The G protein-coupled receptor P2Y14 is activated by UDP, UDP-glucose and other UDP-sugars. Northern blot and qPCR analyses showed that P2Y14 is widely expressed in human and mouse tissues. Most studies focus on P2Y14 presence in immune cells, suggesting a physiological relevance in immune and inflammatory responses. Although the highest expression is found in the gastrointestinal (GI) tract and adipose tissue little is known about the metabolic relevance of P2Y14. Aim: To clarify the physiological role of P2Y14 with specific focus on energy homeostasis we use a P2Y14-deficient mouse model. Methods…