Role of JAK-STAT pathway in pulmonary fibrosis

Rationale: Prior studies suggested a constitutive activation of Signal Transducer and Activator of Transcription 3 (STAT3) in pulmonary fibrosis. STAT3 is part of the Janus Kinase (JAK)-STAT pathway, which is important for developmental regulation, growth control, and hemostasis in multicellular organisms. Several mediators like Interleukin (IL)-4 and Il-13, and factors like Platelet Derived Growth Factor (PDGF), thrombin and angiotensin are involved in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF). These mediators and factors are known to transduce their signal though the JAK-STAT pathway. Little is u…