Gut permeability and serum bile acids in metabolic syndrome

Background: High fat diet can lead to metabolic syndrome and is associated with changes in gut microbiota and gut permeability, possibly mediated by bile acids. The aim of this study was to investigate whether patients with MetS show increased gut permeability and whether this is associated with changes in serum bile acid composition. Methods: Gut permeability was assessed by a differential sugar absorption method and by determination of diaminooxidase (DAO) serum levels. Serum bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid, ursodeoxycholic acid) were determined as unconjugate…