Study of vitamin D metabolism and signaling in human hepatocellular carcinoma and surrounding liver tissues
E Horváth, B Balla, J Kósa, P Lakatos, Á Lazáry, D Németh, H Jozilan, Á Somorácz, A Korompay, B Gyöngyösi, K Borka, A Kiss, P Kupcsulik, Z Schaff, F Szalay · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aim: 1,25-DihydroxyvitaminD3 (1,25(OH)2D3), the active form of vitamin D, mediates antitumor effects mostly by the vitamin D nuclear receptor (VDR) in various cancers. We aimed to examine mRNA and protein expression differences of 1,25(OH)2D3-inactivating CYP24A1 and mRNA expression of the activating CYP27B1 enzymes, as well as that of VDR between human non-tumorous liver and hepatocellular carcinoma (HCC) tissue samples, and to study the correlation with clinicopathological characteristics. Patients and Methods: We evaluated 38 patients who had undergone liver surgery for therapeutic purposes. MRNA expression o…
