Methylation matters: The importance of DNA methylation in colorectal cancer
VÁ Patai, B Barták, B Péterfia, P Hollósi, A Kalmár, Á Patai, G Valcz, B Wichmann, K Tóth, K Leiszter, A Schöller, S Spisák, Z Nagy, Z Tulassay, B Molnár · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Aberrant DNA hypermethylation plays an important role in colorectal carcinogenesis, especially in the proximal colon, where a clinically and molecularly distinct subtype (CpG island methylator phenotype, CIMP) was identified. This subtype has not been described in Hungary before. Most studies addressing DNA methylation have so far focused on the analysis of few, rather than multiple genes. Aims: Our aim was to study DNA methylation in 96 genes in different settings related to colorectal carcinogenesis, including lesions of adenoma-dysplasia-carcinoma sequence (ADCS). We also aimed to define the preva…
