Molecular Characterization of Medulloblastoma Mouse Models -On the Avenue to More Elaborate Preclinical Testing Strategies

Medulloblastoma (MB) is one of the most common malignant brain tumors in children. The current treatment regimen consists of tumor resection and subsequent chemo- and radiotherapy. Long-term morbidity due to this aggressive treatment is a major problem in MB therapy. Recently the extensive molecular characterization of MBs revealed four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. They are defined by different genetic alterations and largely differ in patient age and outcome. Since then our knowledge of underlying pathomechanisms is getting more and more profound, thus nourishing hope for tailor…