Use of Contrast-enhanced ultrasound (CEUS) in systemic mastocytosis. Report of two cases

Introduction: Systemic mastocytosis (SM) is an extremely rare disease characterized by clonal proliferation of abnormal mast cells in several extra-cutaneous organs, such as bone, liver and spleen [1]. Usually, the hepatic lesions appear rounded, hypoechoic on conventional sonogram and without vascular sign on color Doppler ultrasound (CPD). Case 1: A 39-year-old man presented to our Unit because of the persistence of abdominal pain, diarrhea, and vomiting. He reported a history of systemic mastocytosis with bone localizations treated with interferon-alpha. Ultrasound showed hepatomegaly (longitudinal diameter o…