Sequential PAT-expression in human hepatocyte steatosis

Background & Aims: Hepatocellular steatosis is the most frequent liver disease in the western world and may develop further to steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. We have previously shown that lipid droplet (LD)-associated proteins of the perilipin/PAT-family are differentially expressed in hepatocyte steatosis and that perilipin is de novo expressed. Aim of this study was to analyse the modalities of hepatocellular PAT-protein expression especially in relation to the recent development of steatosis and explore its diagnostic potential. Methods: Immunohistochemical PAT-analysis was pe…