Screening for TGFB Signaling Regulator expression in human HCC
T Dediulia, A Dropmann, T Itzel, N Meindl-Beinker, A Teufel, S Cai, P ten Dijke, S Dooley · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocellular carcinoma (HCC) is one of the most deadly malignancies worldwide. Scientists have been studying the molecular mechanisms of HCC for years, but the understanding of it remains incomplete and scattered across the literature at different molecular levels. High-throughput omics technologies have been widely applied and provide large amounts of data. We have been studying the TGF-β signaling pathway in liver diseases for years, which has major impact on disease progression and hepatocarcinogenesis. TGF-β effects are highly cell type and context dependent and downstream signaling is intricately controll…