Expression of myelin auto-antigens and myelin altered peptide ligands in the liver in EAE mice models

Background and Aim: Hepatic expression of an alternated peptide ligand (APL) of myelin basic protein (MBP) leads to protection from experimental autoimmune encephalomyelitis (EAE) in mice. EAE constitutes a mouse model for multiple sclerosis in which MBP is one of the major auto-antigens. Other auto-antigens are myelin oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP). The tolerance is mediated by MBP specific regulatory T cells after conversion of naïve T cells into the regulatory phenotype. Here we investigate the prophylactic and therapeutic potential of liver expressed APLs of MOG and PLP in E…