Metabolomic Imaging for Human Prostate Cancer Detection using MR Spectroscopy at 7-T

To develop a non-invasive diagnostic test for prostate cancer, by analyzing metabolomic maps (including 36 metabolite regions) of the prostate specimen using Magnetic Resonance Spectroscopy (MRS) at 7-T. To test the functionality of this Metabolomic Imaging, the results have been compared with the histopathology findings. MRI/MRS of the middle transverse cross-sectional plane was conducted for 30 whole prostates with biopsy-proven cancer (Siemens 7-T). Then, histopathology of the specimens was graded by an uropathologist. For the processing of the spectral data, an in-house MATLAB-based program was used. After m…