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Pancreatic lipids and insulin secretion in humans with or without type 2 diabetes

P Begovatz, C Koliaki, K Strassburger, B Nowotny, P Nowotny, G Giani, G Pacini, J Bunke, J Szendroedi, M Roden · Diabetologie und Stoffwechsel · 2014 · Heft 05

Dokument
1020598
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Jahr
2014
Publikation
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
P Begovatz, C Koliaki, K Strassburger, B Nowotny, P Nowotny, G Giani, G Pacini, J Bunke, J Szendroedi, M Roden
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-06 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0034-1374964

Zusammenfassung

Objective: This study compared the effects of obesity and pancreas fat on β-cell function, while non-invasively distinguishing between peripancreatic, interlobular, and parenchymal fat. Methods: Forty-eight participants (lean, overweight/obese, type 2 diabetes, 16 per group), underwent a frequent-sampling oral glucose tolerance test (OGTT), magnetic resonance imaging (MRI; whole-body and pancreas) and magnetic resonance spectroscopy (1H-MRS; liver and pancreas). Pancreas fat measurements consisted of standard 2-cm3 1H-MRS, 1-cm3 1H-MRS with localization that aimed to measure parenchymal fat, and a MRI method to…

Schlagworte

Diabetologie und Stoffwechsel