Changes in renal function in pre-diabetic mice overexpressing SREBP-1c

Owing to sterol regulatory element binding protein 1c (SREBP-1c) overexpression in adipose tissue, transgenic aP2-SREBP-1c mice show partial lipodystrophy and ectopic lipid deposition. Hyperinsulinemic-euglycemic clamps performed on these transgenic mice demonstrate that they are hyperinsulinemic and insulin resistant compared to C57BL/6 mice serving as controls. Renal function in these mice has not yet been characterised. Urinary albumin to creatinine ratio measured by ELISA was used to determine kidney function. Kidneys from sacrificed mice were weighed and homogenized for assessment of lipid peroxidation by t…