Adipose tissue mRNA expression of WHR-associated genes correlates with fat distribution
J Krüger, M Prellberg, B Gutsmann, D Schleinitz, J Breitfeld, M Kern, N Klöting, M Blüher, M Stumvoll, P Kovacs · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Body fat distribution (FD) is one of the main predictors of obesity associated complications. There is good evidence that fat distribution is controlled by genetic factors. Recent meta-analysis identified novel loci associated with waist to hip ratio (WHR). Here, we hypothesize that these genes exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Material and Methods: We measured mRNA levels of LYPLAL1, ADAMTS9, VEGFA, CPEB4, RSPO3, ITPR2, SSPN, LY86 in paired human samples of visceral and subcutaneous adipose tissue from 570 individuals with detailed metabolic te…
