Pediatric reference values for insulin from oGTT and prevalence of hyperinsulinemia in obese children

Rationale: Evaluation of glucose metabolism is currently based on 2h glucose during an oGTT or fasting glucose and insulin. This does, however, not adequately reflect the degree of hyperinsulinemia and insulin resistance in obese children. From frequent glucose and insulin levels during an oGTT of 64 healthy lean children we established reference values for insulin secretion in normal children and compared insulin and glucose dynamics with data of 99 obese children. We finally applied these reference data to assess the prevalence of insulin resistance in an extended cohort of 1085 obese children. Results: From h…