Effects of empagliflozin on oxidative stress and endothelial dysfunction in STZ-induced Type 1 diabetic rat
M Oelze, S Kröller-Schön, M Mader, E Zinßius, P Stamm, M Hausding, E Mayoux, P Wenzel, E Schulz, T Münzel, A Daiber · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background, methods: In diabetes, cardiovascular complications are associated with endothelial dysfunction and oxidative stress. Empagliflozin, as a selective sodium glucose cotransporter (SGLT) 2 inhibitor in clinical development, offers a promising novel approach for the treatment of type 2 diabetes by enhancing urinary glucose excretion. The aim of the present study was to test whether treatment with Empagliflozin could improve endothelial dysfunction in type I diabetic rats via reduction of glucotoxicity and associated oxidative stress. Type I diabetes in Wistar rats was induced by an i.v. injection of strep…
