Response of MCF-7 mamma carcinoma cells to glyoxal and methylglyoxal

Background: The α-oxo-aldehydes glyoxal and methylglyoxal are byproducts of fatty acid oxidation and glycolysis. Cancer cells produce significantly more of these aldehydes than other cells due to their high glycolytic activity. These substances are highly reactive and modify proteins. As a result stable, accumulating products, the so called advanced glycation end products (AGEs)are formed. In this study we analysed the responses of the estrogen receptor positive mamma carcinoma cell line MCF-7 to glyoxal and methylglyoxal. Methods: Cell vitality was determined by the resazurin assay. Activation of MAP-kinases an…