Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b

A considerable number of diseases in the mature lung can be related to the deregulation of (embryonic) programs that control the balance between proliferation and differentiation of cells. Pediatric pulmonary hypoplasia is a common cause of neonatal death; consequently, a lot of effort has been put into understanding the network of signaling pathways that assure correct lung growth and development. However the mechanisms of cell cycle control during lung organogenesis were only insufficiently understood. Unraveling these is crucial to understand how tissue homeostasis in the lung is achieved and how deregulation…