The epithelial IL-23R mediates intestinal immune defense and epithelial regeneration
K Aden, A Rehman, R Häsler, F Tran, S Pfeuffer, S Billmann, M Paulsen, S Lipinski, A Kaser, S Schreiber, P Rosenstiel · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: The identification of the IL23R as a genetic risc factor in inflammatory bowel disease (IBD) has highlighted the role of IL-23 signaling in the intestinal immune response. However, the impact of IL-23 on the immune regulation is ambigious. Whereas IL-23 induced Th-17 polarization contributes to pathogenesis of IBD5, IL-23 induced IL-22 in Thy-1+ innate lymphoid cells is indispensable in the innate immune response to bacterial pathogens and experimental colitis. This study aimed to describe the role of the Il23R in the intestinal epithelium. Methods: Conditional knockout of the Il23R in the i…
