The liver microenvironment determines the CSC phenotype in hepatocellular carcinomas
M Fischer, S Heinrich, JB Andersen, S Rösner, M Sprinzl, S Arbogast, I Gockel, MA Wörns, SS Thorgeirsson, PR Galle, H Lang, JU Marquardt · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: The cancer stem cell (CSC) hypothesis is an emerging concept in cancer research and provides a plausible explanation for the observed phenotypic heterogeneity of many cancers including hepatocellular carcinoma (HCC). However, despite profound therapeutic implications the prognostic relevance of CSCs and their cellular localization within the tumor formation remain controversial. Methods: Expression levels and localization of established CSC markers were assessed in 22 HCCs using qRT-PCR, imunohistochemistry and Western-Blotting. Whole transcriptome analyses of different tumor regions as well as tumor…
