A new experimental animal model: contradictory atrophic and regenerative stimuli by combination of portal vein ligation and partial hepatectomy

Background: Portal vein ligation (PVL) leads to atrophy of dependent liver lobes and hypertrophy of intact liver lobes, while partial hepatectomy (PHx) leads to hyperplasia of residual liver lobes. It is unclear that how the portal flow deprived-liver lobes adjust its size under the proliferative stimulus induced by PH. In this study we investigated the size regulation of individual liver lobe in the combined model- PVL+PHx. Material and methods: We established new rodent model of 20% PVL+70% PHx and 70% PVL+20% PHx respectively. Liver lobe size regulation were evaluated 1, 2, 3 and 7 after operation in terms of…