Role of CCL22 in human spontaneous and repeated miscarriage

Treg are a subpopulation of T cells with the capacity of down-regulating the immune response. Infiltration of tissues with Treg is thus associated with immune tolerance. This could be particularly important for the tolerance of the fetus in pregnancy. Several chemokines were described to be responsible for Treg accumulation in human and therefore, potentially play a role in human spontaneous and repeated miscarriage. CCL22 has been described to recruit Treg in human normal and pathological tissues. We found that CCL22 specifically recruits human Tregs in vitro. We aimed to investigate whether CCL22 is expressed…