Hyperestrogenism – just blame the rabbit

A 54-year old women presented in our department with high estradiol levels (> 4300 pg/ml) and yet typical postmenopausal symptoms. She had a history of adnexectomy (normal histo-pathology) due to these elevated levels of estradiol. After surgery, estradiol levels were as high as before. Lab tests for anti-mullerian hormone, estrone and inhibin B showed normal postmenopausal levels. Serum estradiol levels were controlled several times with rabbit derived polyclonal and monoclonal antibodies which represent the common commercial test. Secondary, a radio immune assay was done which already showed lower, but still e…