First trimester oral glucose tolerance test in a population at high risk for gestational diabetes

Gestational diabetes mellitus (GDM) is defined as glucose intolerance, which is first detected during pregnancy. In the current study, we evaluated whether a first trimester 75 g oral glucose tolerance test (oGTT) is useful in stratifying pregnant women at high risk. We screened pregnant women at risk by using a 75 g oGTT at first visit. Later on we changed the screening strategy either by measuring random glucose or glycosylated haemoglobin in the first trimester. If the first trimester oGTT was normal, a second 75 g oGTT was performed between 24 and 28 weeks. Fasting, 1h, and 2h glucose values were compared be…