HER1- HER4- Clinicopathologic analysis of matched pairs: Primary and cerebral metastases of breast cancer
C Bachmann, G Brockhoff, EM Grischke, A Staebler, J Schittenhelm, D Wallwiener · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and Aim: HER2overexpression is a prognostic and predictive factor for development of CNS metastases (BM) in primary breast cancer. Studies have shown that the immunophenotype of distant breast cancer metastases may be different from that of primary tumour, leading to inappropriate choice of systemic treatment. A number of studies have demonstrated that HER3overexpression is associated with poor prognosis and HER4 is more related with a favourable prognosis in breast cancer. Aim is to detect if there is receptor change for ER/PR and HER1 – 4 status in matched pairs of BM and primary. Methods: 24 consec…
