Mitotic regulation of the mitotic centromere-associated kinesin

Deregulated mitotic centromere-associated kinesin (MCAK) is associated with cancer invasiveness, metastasis and poor prognosis of patients. It is thus important to delineate the regulatory mechanisms responsible for regulating MCAK's turnover. MCAK depolymerizes microtubules, controls microtubule dynamics and has been tightly linked to the correction of fail-attachments between kinetochores and microtubules in mitosis. Its activity and localization are regulated via phosphorylation by important mitotic kinases. The exact picture of MCAK regulation by these kinases during mitosis remains elusive and needs to be c…