CareLit Fachartikel

Early discontinuation of chemotherapy among elderly patients with ovarian cancer under clinical trial conditions – an analysis of the AGO study group

S Saß, J Hedderich, AM Hempel, P Harter, S Mahner, J Pfisterer, A du Bois, F Hilpert · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09

Dokument
1021078
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
S Saß, J Hedderich, AM Hempel, P Harter, S Mahner, J Pfisterer, A du Bois, F Hilpert
Ausgabe
Heft 09 / 2014
Seiten
–
Erschienen: 2014-09-05 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0034-1388574

Zusammenfassung

Age is a negative prognostic factor for survival in ovarian cancer (OC) even under controlled clinical trial conditions. The number of chemotherapy (CTX) cycles is an independent prognostic factor for survival in elderly patients (EP) in previous results. Now we analysed the reasons for early discontinuation (ED) in EP receiving platinum/taxane-based CTX in advanced OC. Datasets from 3 randomized phase-III trials (AGO-OVAR 3, 5, 7) investigating platinum/taxane-based chemotherapy in OC FIGO IIB-IV were merged into a combined meta-dataset. 359 (10.8%) EP ≥70 years of age out of 3333 patients who had received at l…

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