CareLit Fachartikel

Pregnancy – A natural vaccination against tumor-associated antigens of the breast?

M Boudewijns, A Krause, P Beckhove, C Sohn, C Domschke, F Schütz · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09

Dokument
1021079
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
M Boudewijns, A Krause, P Beckhove, C Sohn, C Domschke, F Schütz
Ausgabe
Heft 09 / 2014
Seiten
–
Erschienen: 2014-09-05 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0034-1388584

Zusammenfassung

Objectives: Epidemiological studies have demonstrated that parity is a factor associated with decreased lifetime risk of developing breast cancer. Coincidental, breast carcinomas overexpress a range of tumor associated antigenes (TAA) such as the carcinoembryonic antigen (CEA), Mucin-1, and Her2. The objective of our study was to identify the impact of pregnancy on the presence of TAA-specific T-cell immunity and the incidence leading to an induction of TAA-specific regulatory T-cells (Treg). Methods: We monitored the existence of TAA-specific T-cells of altogether 52 healthy individuals and 65 patients diagnose…

Schlagworte

Breast After Carcinoma in Situ Tumor Mucin-1 Antigens Geburtshilfe und Frauenheilkunde