HDAC10: a novel drug target for childhood tumors of the nervous system

The histone deacetylase (HDAC) family is comprised of diverse enzymes that are divided into different classes and are involved in many cellular processes, very often linked to tumor biology. Here, we introduce the class IIb enzyme HDAC10 as a potential drug target for the treatment of childhood tumors of the nervous system, such as medulloblastoma. The evolutionarily highly conserved process of autophagy helps aggressive tumors to survive stressful conditions such as chemotherapy. Interference with this survival mechanism is a potential novel strategy to sensitize tumor cells to chemotherapy. We have recently sh…